Drs. Catalyurek, Huang, and Parvin have been awarded an NIH/NCI R01 grant
Tuesday 08/11/2009
Drs. Parvin, Catalyurek and Huang have been awarded an NIH/NCI R01 grant titled "Informatics methods for identifying breast cancer control genes and proteins."
This project combines innovative informatics methods with biological experiments in order to identify proteins that collaborate with breast cancer control genes. Data from gene chips will be analyzed using a variety of informatics tools to identify proteins that function in the same pathways as the breast cancer specific tumor suppressors BRCA1 and BRCA2. Candidate “BRCA” proteins will be tested using biological assays for DNA repair and control of the cellular organelle called the centrosome. Those proteins that are positive in the biological tests will then be tested in breast cancer samples as potential biomarker for breast cancer. This project will identify new genes that contribute to the breast cancer process and will develop new diagnostic tools.