BMI-authored Manuscript Accepted for Publication in Mainstream Pathology Journal
Tuesday 02/05/2008
The OSU Department of Biomedical Informatics is proud to announce that one of its latest manuscripts has been accepted for publication in the prestigious Archives of Pathology & Laboratory Medicine journal. The manuscript "Computer-assisted Grading of Neuroblastic Differentiation" will be featured in an upcoming issue.
Below is a summary of the manuscript [written by Jun Kong]:
Peripheral Neuroblastic Tumors (pNTs; neuroblastoma,
ganglioneuroblastoma, ganglioneuroma) are members of one of the most
frequently-occurring tumor groups in children. The current prognostic
evaluation for patients with this disease requires microscopic
examination of tumor tissues for determining certain morphological
characteristics by pathologists. Since this process inevitably involves
visual evaluation, the prognosis decision would often be subject to
inter- and intra-reviewer variability as experience, fatigue and many
other factors could affect the decision making process, and as a result,
potentially degrading the reproducibility. Thanks to the advent of
modern digital scanners, it is now feasible to scan the whole
neuroblastoma tissue specimens and acquire the whole-slide digital
images. Computerized analysis of these images can generate key
quantifiable parameters useful in the prognostic evaluation and, thus,
assist pathologists.
We have developed a novel system to determine the grade of neuroblastic
differentiation that can be used for the prognostic evaluation of
neuroblastoma. Equipped with this system, pathologists can work more
efficiently in their histopathology review of neuroblastoma, leading to
a potential improvement of reproducibility.