OSU Department of Biomedical Informatics

Jeffrey D. Parvin M.D, Ph.D.

Interim Chair and Professor

phone: (614) 292-0523
fax: (614) 688-6600

email:



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mailing address
904 Biomedical Research Tower
460 W. 12th Ave.
Columbus, OH 43210


Dr. Parvin received his B.S. from Haverford College, his Ph.D. and M.D. from Mt. Sinai School of Medicine, and his Postdoc from MIT. Before joining the Ohio State University in May of 2007, he was an Assistant and Associate Professor of Pathology at Harvard Medical School, and a Research Pathologist at Brigham and Women's Hospital in Boston.

Project Involvement

Medical Informatics

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Grant Highlights


Patents

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P. Palese, A. Garcia-Sastre, M. Krystal, Jeffrey D. Parvin, "Recombinant negative strand RNA virus expression systems and vaccines", US Patent 11/244,119 Filed 2005-10-04 and Issued 2005-10-04.

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Publications

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Satish Sankaran, Donna E. Crone, Robert E. Palazzo, Jeffrey D. Parvin, "Aurora A Kinase Regulates BRCA1 Inhibition of Centrosome-Dependent Microtubule Nucleation", Cancer Research, 67 : pp. 11186-11194, December, 2007.

Satish Sankaran, Donna E. Crone, Robert E. Palazzo, Jeffrey D. Parvin, "BRCA1 regulates gamma-tubulin binding to centrosomes", Cancer Biology and Therapy, 6 (12) : pp. 1853 - 1857, October, 2007.

Miguel A. Pujana, Jing-Dong J Han, Lea M. Starita, Kristen N. Stevens, Muneesh Tewari, Jin So Ahn, Gad Rennert, Victor Moreno, Tomas Kirchhoff, Bert Gold, Volker Assmann, Wael M. ElShamy, Jean-François Rual, Douglas Levine, Laura S. Rozek, Rebecca S. Gelman, Kristin C. Gunsalus, Roger A. Greenberg, Bijan Sobhian, Nicolas Bertin, Kavitha Venkatesan, Nono Ayivi-Guedehoussou, Xavier Solé, Pilar Hernández, Conxi Lázaro, David E. Hill, Kenneth Offit, David M. Livingston, Stephen B. Gruber, Jeffrey D. Parvin, Barbara L. Weber, Marc Vidal, "Network modeling links breast cancer susceptibility and centrosome dysfunction", Nature Genetics, 39 : pp. 1338-1349, October, 2007.

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Presentations

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Jeffrey D. Parvin, "Cellular Response to DNA Damage", in Proceedings of Cellular Responses to DNA Damage meeting, Boston, Massachusetts, 2007

Patents

click to hide (-)

P. Palese, A. Garcia-Sastre, M. Krystal, Jeffrey D. Parvin, "Recombinant negative strand RNA virus expression systems and vaccines", US Patent 11/244,119 Filed 2005-10-04 and Issued 2005-10-04.

Publications

click to hide (-)

Satish Sankaran, Donna E. Crone, Robert E. Palazzo, Jeffrey D. Parvin, "Aurora A Kinase Regulates BRCA1 Inhibition of Centrosome-Dependent Microtubule Nucleation", Cancer Research, 67 : pp. 11186-11194, December, 2007.

Satish Sankaran, Donna E. Crone, Robert E. Palazzo, Jeffrey D. Parvin, "BRCA1 regulates gamma-tubulin binding to centrosomes", Cancer Biology and Therapy, 6 (12) : pp. 1853 - 1857, October, 2007.

Miguel A. Pujana, Jing-Dong J Han, Lea M. Starita, Kristen N. Stevens, Muneesh Tewari, Jin So Ahn, Gad Rennert, Victor Moreno, Tomas Kirchhoff, Bert Gold, Volker Assmann, Wael M. ElShamy, Jean-François Rual, Douglas Levine, Laura S. Rozek, Rebecca S. Gelman, Kristin C. Gunsalus, Roger A. Greenberg, Bijan Sobhian, Nicolas Bertin, Kavitha Venkatesan, Nono Ayivi-Guedehoussou, Xavier Solé, Pilar Hernández, Conxi Lázaro, David E. Hill, Kenneth Offit, David M. Livingston, Stephen B. Gruber, Jeffrey D. Parvin, Barbara L. Weber, Marc Vidal, "Network modeling links breast cancer susceptibility and centrosome dysfunction", Nature Genetics, 39 : pp. 1338-1349, October, 2007.

George Heine, Jeffrey D. Parvin, "BRCA1 Control of Steroid Receptor Ubiquitination", Science STKE 2007, (391) : pp. pe34, June, 2007.

Andrew A. Horwitz, El Bachir Affar, George Heine, Yang Shi, Jeffrey D. Parvin, "A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase", Proc Natl Acad Sci USA, 104 (16) : pp. 6614-6619, April, 2007.

E. Kontopoulos, Jeffrey D. Parvin, M. Feany, "Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity", Human Molecular Genetics, 15 (20) : pp. 3012-23, October, 2006.

Jeffrey D. Parvin, Satish Sankaran, "The BRCA1 E3 ubiquitin ligase controls centrosome dynamics", Cell Cycle 2006, 5 (17) : pp. 1946-1950, September, 2006.

Satish Sankaran, Jeffrey D. Parvin, "Centrosome function in normal and tumor cells", Journal of Cellular Biochemistry 2006, 99 (5) : pp. 1240-1250, June, 2006.

JA Toretsky, V. Erkizan, A. Levenson, OD Abaan, Jeffrey D. Parvin, TP Cripe, AM Rice, SB Lee, A. Üren, "Oncoprotein Ews-Fli1 Activity Is Enhanced By RNA Helicase A (RHA)", Cancer Res 2006, 66 (11) : pp. 5574-81, June, 2006.

Satish Sankaran, LM Starita, AM Simons, Jeffrey D. Parvin, "Identification of domains of BRCA1 critical for the ubiquitin-dependent inhibition of centrosome function", Cancer Research 2006, 66 (8) : pp. 4100-4107, April, 2006.

AM Simons, Andrew A. Horwitz, LM Starita, RS Williams, K. Griffin, JNM Glover, Jeffrey D. Parvin, "BRCA1 DNA binding activity is stimulated by BARD1", Cancer Research 2006, 66 : pp. 2012-2018, February, 2006.

Andrew A. Horwitz, Satish Sankaran, Jeffrey D. Parvin, "Direct stimulation of transcription initiation by BRCA1 requires both its amino and carboxy-termini", J Biol Chem 2006, 281 : pp. 8317-20, February, 2006.

LM Starita, Jeffrey D. Parvin, "Substrates of the BRCA1 dependent ubiquitin ligase", Cancer Biology and Therapy 2006, 5 (2) : pp. 137-141, February, 2006.

DY Takeda, Y. Shibata, Jeffrey D. Parvin, A. Dutta, "Recruitment of replication factors to DNA is sufficient to stimulate replication initiation in mammalian cells", Genes Development 2005, 19 : pp. 2827-2836, September, 2005.

MJ Ko, K. Murata, DS Hwang, Jeffrey D. Parvin, "Inhibition of BRCA1 in breast cell lines causes the centrosome duplication cycle to be disconnected from the cell cycle", Oncogene 2006, 25 : pp. 298-303, September, 2005.

Satish Sankaran, LM Starita, AC Groen, MJ Ko, Jeffrey D. Parvin, "Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination", Molecular and Cellular Biology 2005, 25 (19) : pp. 8656-8668, July, 2005.

Presentations

click to hide (-)

Jeffrey D. Parvin, "Cellular Response to DNA Damage", in Proceedings of Cellular Responses to DNA Damage meeting, Boston, Massachusetts, 2007

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